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Creators/Authors contains: "Tabakovic, Ibro"

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  1. Ferromagnetic Co 35 Fe 65 , Fe, Co, and Ni nanowires have high saturation magnetizations ( M s ) and magnetic anisotropies, making them ideal for magnetic heating in an alternating magnetic field (AMF). Here, Au-tipped nanowires were coated with polyethylene glycol (PEG) and specific absorption rates (SAR) were measured in glycerol. SAR increased when using metals with increasing M s (Co 35 Fe 65 > Fe > Co > Ni), reaching 1610 ± 20 W g −1 metal at 1 mg metal per ml glycerol for Co 35 Fe 65 nanowires using 190 kHz and 20 kA m −1 . Aligning these nanowires parallel to the AMF increased SAR up to 2010 W g −1 Co 35 Fe 65 . Next, Co 35 Fe 65 nanowires were used to nanowarm vitrified VS55, a common cryoprotective agent (CPA).Nanowarming rates up to 1000 °C min −1 (5 mg Co 35 Fe 65 per ml VS55) were achieved, which is 20× faster than the critical warming rate (50 °C min −1 ) for VS55 and other common CPAs. Human dermal fibroblast cells exposed to VS55, and Co 35 Fe 65 nanowire concentrations of 0, 1 and 2.5 mg Fe per ml all showed similar cell viability, indicating that the nanowires had minimal cytotoxicity. With the ability to provide rapid and uniform heating, ferromagnetic nanowires have excellent potential for nanowarming cryopreserved tissues. 
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